The future of enterprise groupware applications

This paper provides a review of groupware technology and products. The purpose of this review is to investigate the appropriateness of current groupware technology as the basis for future enterprise systems and evaluate its role in realising, the currently emerging, Virtual Enterprise model for business organisation. It also identifies in which way current technological phenomena will transform groupware technology and will drive the development of the enterprise systems of the future

Audio-haptic interfaces for digital audio workstations: A participatory design approach

We examine how auditory displays, sonification and haptic interaction design can support visually impaired sound engineers, musicians and audio production specialists access to digital audio workstation. We describe a user-centred approach that incorporates various participatory design techniques to help make the design process accessible to this population of users. We also outline the audio-haptic designs that results from this process and reflect on the benefits and challenges that we encountered when applying these techniques in the context of designing support for audio editing

Mechanism of Werner DNA Helicase: POT1 and RPA Stimulates WRN to Unwind beyond Gaps in the Translocating Strand

WRN belongs to the RecQ family of DNA helicases and it plays a role in recombination, replication, telomere maintenance and long-patch base excision repair. Here, we demonstrate that WRN efficiently unwinds DNA substrates containing a 1-nucleotide gap in the translocating DNA strand, but when the gap size is increased to 3-nucleotides unwinding activity significantly declines. In contrast, E. coli UvrD (3′→5′ helicase), which recognizes nicks in DNA to initiate unwinding, does not unwind past a 1-nucleotide gap. This unique ability of WRN to bypass gaps supports its involvement in DNA replication and LP-BER where such gaps can be produced by glycosylases and the apurinic/apyrimidinic endonuclease 1 (APE1). Furthermore, we tested telomere repeat binding factor 2 (TRF2), both variants 1 and 2 of protector of telomeres 1 (POT1v1 and POT1v2) and RPA on telomeric DNA substrates containing much bigger gaps than 3-nucleotides in order to determine whether unwinding could be facilitated through WRN-protein interaction. Interestingly, POT1v1 and RPA are capable of stimulating WRN helicase on gapped DNA and 5′-overhang substrates, respectively

Procurement impacts on construction supply chains: UK experiences

SCM has long been advocated as a means of improving the performance of supply chains in construction. SCM can be defined as a network of different organisations, linked upstream and downstream in a chain, aiming to produce quality and value in the services and products for the end consumers through integrated processes and activities. The drive for SCM has frequently come from the public and private sector client base. With one of the purposes being to achieve increased levels of integration of the whole supply chain, the industry has had to respond to drivers embedded in the changed procurement arrangements that have been implemented. This paper reports on an investigation into the impact of changed procurement systems on supply chain firms in the UK. It will discuss different initiatives by clients and by the UK government in order to drive some form of supply chain integration